I've been spending quite a bit of time in FlexBuilder lately, and have started to rely extensively on some shortcuts. Some of these are actually Eclipse shortcuts, but regardless, these are some of my favorite:
 
  • Ctrl-F11: Run
  • F11: Debug
  • Ctrl-Alt-Down: Repeat current line
  • Alt-Up: Move line (or selection) up
  • Alt-Down: Move line (or selection) down
  • Ctrl-Click: Go to definition (also F3)
  • Ctrl-D: Delete line
  • Alt-/: Word completion (cycles through possible matches)
  • Ctrl-Up: Scroll up
  • Ctrl-Down: Scroll Down
 What shortcuts do you rely on? Please share!